Clinical Impact of Dedicated MR Staging of Ovarian Cancer (MRStagingOC)

Netherlands Cancer Institute (NKI)

Status: Unknown

Conditions: Ovarian Cancer

Treatments: Other: MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT03399344

M17MRO

Details and patient eligibility

About

The only chance of cure for patients with advanced stage ovarian cancer is complete cytoreductive surgery (CRS). The only way to determine whether complete CRS can be achieved is by a laparoscopy. However, diffusion-weighted magnetic resonance imaging (DW-MRI) has a very high sensitivity to detect small volume malignant disease, making it a potentially suitable staging tool. Aim of this study is to determine the performance of DW-MRI for predicting whether complete CRS can be achieved.

Enrollment: 270 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with advanced stage (FIGO stage III or IV) ovarian cancer scheduled for primary or interval cytoreductive surgery
• Age >18 years
• Written and signed informed consent
• WHO 0-2
• Able to read and write Dutch

Exclusion criteria

• Patients with contraindications for MRI
• Patients with contraindications for CRS
• Known additional malignancy

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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270 participants in 1 patient group

DW-MRI

Other group

Description:

Patients with undergo an additional diffusion-weighted MRI in addition to the standard diagnostic work-up

Treatment:

Other: MRI