Clinical Implementation of TNM-immunoscore in Resected Non-small Cell Lung Cancer (TNM-I)

University Hospital of North Norway

Status: Active, not recruiting

Conditions: Non-Small Cell Lung Cancer

Treatments: Other: Will look for immune infiltration

Study type: Observational

Funder types: Other

Identifiers

NCT03299478

2016/714

Details and patient eligibility

About

The purpose of this study is to validate TNM-Immunoscore in resected non-small cell lung cancer.

Full description

The main aim is to validate the most promising T-cell marker candidates from earlier studies in a prospective multicenter study to establish a prognostic TNM-Immunoscore.

The investigators will include around 1000 stage I-IIIA patients from various centers in Scandinavia. The investigators will also collect demographic and clinicopathological data, blood and tissues in a database and biobank. Candidate T-cell markers will be analyzed by immunohistochemistry for validation and by other methods for exploration of their impact on prognosis

Enrollment: 865 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• resectable NSCLC
• Age 18 and above
• no other malignancy last 5 years
• informed consent

Exclusion criteria

• multiple tumor foci
• preoperative chemo- or radiotherapy
• non-NSCLC histology
• no tissue available for study
• metastasis

Trial design

865 participants in 1 patient group

NSCLC patients

Description:

Resected NSCLC patients with curative intent

Treatment:

Other: Will look for immune infiltration