Clinical Investigation of Infections Due to Leishmanial Parasites

National Institute of Allergy and Infectious Diseases (NIAID) logo

National Institute of Allergy and Infectious Diseases (NIAID)

Status

Completed

Conditions

Leishmaniasis, Visceral
Leishmaniasis

Study type

Observational

Funder types

NIH

Identifiers

NCT00001169
79-I-0144
790144

Details and patient eligibility

About

Mechanisms of host immune response to intracellular protozoa will be investigated in patients with naturally acquired infection employing a variety of in-vitro techniques. Both non-specific and antigen-specific humoral and cellular immune responses will be assessed. Parasites will be isolated from patients, cultivated in-vitro, and characterized. Responses to chemotherapy will be assessed parasitologically, immunologically and clinically.

Full description

The main purpose of this protocol is to permit us to see patients who are referred to us for diagnosis and treatment of known or suspected leishmaniasis (from the Peace Corps, Smithsonian Institution, tourists, etc.). In the process of working up these patients, we sometimes encounter parasite isolates that are useful for research. We also can perform tests of cell-mediated immune function to evaluate how patients are responding to therapy. In addition, the protocol permits us to observe therapeutic responses to other drugs besides pentavalent antimony, if necessary.

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Must be between the ages of 1 and 65 years.

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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