Clinical Investigation of the Efficacy of CGF and Ozone in the Treatment of Alveolar Osteitis

T.C. ORDU ÜNİVERSİTESİ

Status: Completed

Conditions: Alveolar Osteitis

Treatments: Other: Traditional treatment; Other: CGF; Device: Ozone

Study type: Interventional

Funder types: Other

Identifiers

NCT04507009

A-2005

Details and patient eligibility

About

The aim of this study is to investigate the efficacy of CGF and Ozone in the treatment of alveolitis and to develop a new treatment protocol that can enable a quick and effective solution of this clinical problem, which significantly affects patients' comfort of life.

Full description

In the present study, 60 healthy patients > 18 years old and have alveolitis, will included. 60 patient will divided randomly into three groups as Control, Ozone and Ozone+CGF. After irrigation of the sockets alvogyl, ozone and ozone+CGF will applied to the sockets respectively. Post operative pain, will measured at 1st to 7th days. Post operative infection, and granulation tissue will measured at 1st, 3rd and 7th days. Oral hygiene will evaluated at first visit. Quality of life will evaluated at 7th day.

Enrollment: 60 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients who have one or more of the following in addition to severe pain, which occur within and around the socket 1-3 days after extraction and do not decrease with pain killers;

• With a partially or completely disintegrated blood clot in the socket
• With exposed bone that gives a dark gray appearance
• With bad odor

Exclusion criteria

• Who does not want to be volunteer for the study,
• Smokers,
• During pregnancy or lactation,
• Has a chronic systemic disorder that will affect recovery,
• Has hematological disorder
• Cooperation cannot be established,
• Previously received radiotherapy or chemotherapy,
• Patients using oral contraceptives

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 3 patient groups

Control

Active Comparator group

Description:

Traditional treatment group which alvogyl applied to the socket after irrigation

Treatment:

Other: Traditional treatment

Ozone

Experimental group

Description:

Ozone group which Ozone (O3) applied after irrigation of the socket

Treatment:

Device: Ozone

CGF +Ozone

Experimental group

Description:

CGF + Ozone group which concentrated growth factor (CGF) after Ozone (O3) applied followed by irrigation of the socket.

Treatment:

Other: CGF

Device: Ozone