Clinical, Molecular and Metabolic Characteristics of Parkinson's Disease (PD) Patients With Parkin Mutation

Groupe Hospitalier Pitie-Salpetriere

Status: Unknown

Conditions: Parkinson's Disease

Treatments: Device: positron emission tomography

Study type: Interventional

Funder types: Other

Identifiers

NCT00169364

P011104

Details and patient eligibility

About

Parkinson's disease is a frequent neurodegenerative disorder. Genetic forms of the disease have been recently identified. The monogenic form due to parkin mutation is responsible for many familial cases and sporadic forms. However, the relationship between the mutation and the genotype of patients is not fully established. The aim of this study is to compare clinical, metabolic and neuropsychological characteristics obtained in patients with parkin mutation with those of patients without parkin mutation.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Juvenile Parkinson's disease (< 45 years)
• Parkin mutation
• Normal brain magnetic resonance imaging (MRI)

Exclusion criteria

• Contraindication to brain MRI
• Women without effective contraception

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)