Clinical Observation of Titration Induction and Convention Induction of Propofol

Lihong Chen

Status: Completed

Conditions: Propofol Overdose of Undetermined Intent

Treatments: Procedure: titration induction to propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT02199522

DDMZ-1

Details and patient eligibility

About

As we know propofol is popular use in the anesthesia induction with kilogram and it always cause hypotension. So we compare haemodynamic changes and drug consumption between propofol titrated administration and traditional administration for anesthesia induction.

Full description

GroupⅠreceived propofol 2 mg/kg intravenously by Fresenius pump at the speed of 250 mg/min, GroupⅡreceived propofol intravenously by Fresenius pump at the speed of 1 mg/kg/min, and observe's assessment of alertness and sedation(OAA/S) scale of the patients was titrated to 1, then changed to a maintenance dose

Enrollment: 160 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with American Society of Anesthesiologists(ASA)Ⅰor Ⅱ and aged 18-60 yr, who were scheduled for general anesthesia.

Exclusion criteria

• Hypertension, Severe heart,pulmonary,brain，liver and renal dysfunction; excess obesity , predicted difficult intubation,hearing obstacles;. Allergic to propofol or its fat emulsion;addictive to sedative and other drugs.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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160 participants in 2 patient groups

titration induction of propofol

Experimental group

Description:

titration induction of propofol by Fresenius pump at the speed of 1 mg•kg-1•min-1

Treatment:

Procedure: titration induction to propofol

convention induction of propofol

No Intervention group

Description:

propofol 2mg•kg-1 intravenously by Fresenius pump at the speed of 250mg•min-1