Clinical Observation of Topical Lidocaine Cream Combined With Moisturizing Cream in the Treatment of Atopic Dermatitis

First Affiliated Hospital of Kunming Medical University

Status: Completed

Conditions: Atopic Dermatitis

Treatments: Drug: Experimental lidocaine cream + moisturizer cream; Drug: Control lidocaine cream

Study type: Interventional

Funder types: Other

Identifiers

NCT07067541

2023-L-88

Details and patient eligibility

About

Twenty-five patients with atopic dermatitis applied lidocaine cream plus a moisturizer to the right limb and lidocaine cream alone to the left limb, twice daily for four weeks.

Enrollment: 25 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Male or female patients aged 18-65 years.
2. Clinical diagnosis of atopic dermatitis according to the 2020 Guidelines for the Diagnosis and Treatment of Atopic Dermatitis in China (symmetrical eczematous lesions for ≥6 months plus personal/family atopy history or elevated IgE/eosinophilia).
3. Voluntarily signed informed consent form.

Exclusion criteria

1. Active heart, liver, kidney, or other serious systemic illness.
2. History of viral or bacterial infection within 1 month prior to enrollment.
3. Immunocompromised patients or those receiving systemic immunosuppressive therapy.
4. Known allergy to lidocaine, moisturizer components, or any study-related topical agents.
5. Pregnant or breastfeeding women.
6. Use of topical corticosteroids or calcineurin inhibitors within 2 weeks prior to enrollment.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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25 participants in 2 patient groups

Control Group

Active Comparator group

Treatment:

Drug: Control lidocaine cream

Experimental group

Experimental group

Treatment:

Drug: Experimental lidocaine cream + moisturizer cream