Clinical Outcome Modelling of Rapid Dynamics in Acute Stroke

King's College Hospital NHS Trust

Status: Enrolling

Conditions: Stroke

Treatments: Other: Body motion categorisation

Study type: Observational

Funder types: Other

Identifiers

NCT04641286

MR/T005351/1 (Other Grant/Funding Number)

KCH20-069

Details and patient eligibility

About

Stroke - still the second commonest cause of death and principal cause of adult neurological disability in the Western World - is characterised by rapid changes over time and marked variability in outcomes. A patient may improve or deteriorate over minutes, and the resultant disability may range from an obvious complete paralysis to subtle, task dependent incoordination of a single limb.

Unlike many other neurological disorders, stroke can be exquisitely sensitive to prompt and intelligently tailored treatment, rewarding innovation in the delivery of care with real-world, tangible impact on patient outcomes. Optimal treatment therefore requires both detailed characterisation of the patient's clinical picture and its pattern of change over time.

Arguably the most important aspect of the patient's clinical picture -- body movement -- remains remarkably poorly documented: quantified only subjectively and at infrequent intervals in the patient's clinical evolution. The combination of artificial intelligence with high-performance computing now enables automatic extraction of a patient's skeletal frame resolved down to major joints, like that of a stick-man, to be delivered simply, safely, and inexpensively, without the use of cumbersome body worn markers. Central to this technology is patient privacy, with the skeletal frame extracted in real time, ensuring no video data, from which patients can be identified, to be stored or transmitted by the device.

Our motion categorisation system -- MoCat -- will be used to study the rapid dynamics of acute stroke, seamlessly embedded in the clinical stream. By quantifying the change in motor deficit over time we shall examine the relationship between these trajectories with clinical outcomes and develop predictive models that can support clinical management and optimise service delivery.

Enrollment: 8,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Putative diagnosis of an acute stroke
• Admission on the stroke unit

Exclusion criteria

• Under 18 years of age

Trial design

8,000 participants in 1 patient group

Stroke

Description:

Individuals admitted to the Hyper Acute Stroke Unit.

Treatment:

Other: Body motion categorisation