Clinical Outcomes After Acute Pulmonary Embolism (ERASE PE)

Insel Gruppe AG, University Hospital Bern

Status: Enrolling

Conditions: Pulmonary Embolism

Study type: Observational

Funder types: Other

Identifiers

NCT04355975

4303 - 2019-02042

Details and patient eligibility

About

To investigate safety and effectiveness of PE treatment according to the decision of the multi-disciplinary pulmonary embolism response team (PERT) and to define and optimize treatment indications, institutional algorithms and interventional techniques for PE.

Full description

This single-center cohort study is designed to retrospectively and prospectively collect treatment and outcome data related to patients with PE and after activation of the PERT. Treatment information and outcomes after advanced treatment modalities, including systemic thrombolysis, catheter directed thrombolysis and surgical embolectomy, will be collected.

Retrospective patient data will consist of treatment and health related outcomes of consecutive patients treated for acute and chronic PE between October 2017 and April 2020 (to assess the learning curve of the PERT) and of patients receiving surgical embolectomy between January 2001 and April 2020. The retrospective data will be derived from the local institutional dataset and will be transferred to the study database. Prospective patients will be included after May 2020.

Enrollment: 800 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Consecutive patients with pulmonary embolism matching the criteria for treatment according to the decision of the PERT.
• Written informed consent

Exclusion criteria

• High probability of non-adherence to the follow up requirements

Trial design

800 participants in 4 patient groups

Medical Therapy / Anticoagulation

Systemic Lysis

Interventional Therapy for PE

Surgical Embolectomy