Clinical Outcomes in Hereditary Cancer

Memorial Sloan Kettering Cancer Center (MSK)

Status: Withdrawn

Conditions: Breast Cancer; Pancreatic Cancer

Treatments: Other: Genotyping

Study type: Observational

Funder types: Other

Identifiers

NCT00580021

06-004

Details and patient eligibility

About

Compare the clinical characteristics and post-surgical outcomes (overall survival)of pancreatic cancer patients of Ashkenazi descent with or without germline founder mutations in BRCA1 or BRCA2 .

Compare the clinical characteristics and outcomes (time to progression) of breast cancer patients of Ashkenazi descent with or without germline founder mutations in BRCA1 or BRCA2 receiving paclitaxel chemotherapy for metastatic disease.

Full description

Compare the clinical characteristics and post-surgical outcomes (overall survival)of pancreatic cancer patients of Ashkenazi descent with or without germline founder mutations in BRCA1 or BRCA2 .

Compare the clinical characteristics and outcomes (time to progression) of breast cancer patients of Ashkenazi descent with or without germline founder mutations in BRCA1 or BRCA2 receiving paclitaxel chemotherapy for metastatic disease.

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Included in DB0363-03
• Jewish religious preference at registration
• Archival material available for testing
• Adequate post-surgical follow-up
• Jewish religious preference at registration
• Archival material available for testing
• Adequate follow-up to determine time to progression

Exclusion criteria

-Subjects will not be included in the analyses if a DNA sample cannot be obtained.

Trial design

0 participants in 1 patient group

1

Description:

Patients with breast and pancreas cancer.

Treatment:

Other: Genotyping