Clinical Outcomes Of Modified Del Nido Cardioplegia In Adult And Pediatric Cardiac Surgery

Superior University

Status: Active, not recruiting

Conditions: Cardiac Events

Treatments: Combination Product: Del Nido cardioplegia

Study type: Observational

Funder types: Other

Identifiers

NCT06744088

MSAHS/Batch-Spring23/007

Details and patient eligibility

About

"Introduction: Modern cardiac surgery prioritizes myocardial protection, incorporating various strategies including cardioplegia to preserve heart function during surgery. The Del Nido (DN) cardioplegia solution, initially for pediatric use, shows promise in adult surgeries due to its longer protection duration and reduced re-dosing needs. However, its efficacy in adults remains under-researched.

Full description

This study aims to evaluate the clinical outcomes of modified Del Nido cardioplegia in adult and pediatric cardiac surgeries, comparing intraoperative and postoperative metrics to provide evidence on its efficacy and safety.

To assess the clinical outcomes of modified Del Nido cardioplegia in cardiac surgeries across different age groups, focusing on myocardial protection, hemodynamic stability, surgical outcomes, recovery, and complications.

Enrollment: 200 patients

Sex: All

Ages: 1 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All Pediatric patients with congenital heart diseases.
• Individuals who are capable of giving their informed permission;
• Stable patients undergoing surgical procedures that involve cardiopulmonary bypass and cardiac arrest;
• isolated CABG surgery, or simultaneous CABG;
• isolated single-valve surgery or multiple value procedures.

Exclusion criteria

• Previous cardiac surgery
• Patients with preoperative inotropic pharmacologic support
• Patients receiving preoperative mechanical circulatory support,
• Patients with an implanted pacemaker or implantable cardioverter-defibrillator,
• Patients undergoing cardiac surgical procedures
• Patients who underwent off-pump or beating heart CABGs
• Ventilation for the night was scheduled because of severe pulmonary arterial hypertension.
• mediastinal drain causing a delay in extubation, or the need to reopen for bleeding or tamponade.