Clinical Outcomes of Patients With Deferred Revascularization Based on FFR and iFR Negative Coronary Artery Lesions.

Aga Khan University Hospital, Pakistan

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Diagnostic Test: Fractional flow reserve, instantaneous wave-free Ratio

Study type: Observational

Funder types: Other

Identifiers

NCT05240768

2020-3681-10742

Details and patient eligibility

About

The objective is to assess long-term clinical outcomes of patients in whom intervention of coronary lesions was deferred due to negative fractional flow reserve (FFR) and negative Instantaneous wave-free ratio (iFR) in a real-world patient population and to identify factors associated with deferred target lesion failure.

Full description

Fractional flow Reserve (FFR) evaluates functional significance of stenosis in intermediate coronary lesions. Instantaneous wave-free ratio (iFR) is considered noninferior to FFR and does not require adenosine administration.

This study was done to assess long-term clinical outcomes and factors associated with target vessel revascularization (TVR) in patients with deferred revascularization based on negative FFR and iFR.

Retrospective analysis of medical records of 345 patients with deferred revascularization at a tertiary care hospital , from January 2012 to January 2020 will be done.

Enrollment: 345 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who had intermediate to severe coronary lesions on coronary angiogram.
• Patients who had negative FFR >0.80 or iFR >0.89 and did not undergo immediate or planned revascularization on basis of negative physiologic assessment.

Exclusion criteria

• Patients younger than 18 years of age or those having positive FFR/iFR values irrespective of revascularization status were excluded.
• Similarly, those who were lost to follow up and could not be traced via telephonic or were also excluded.