Clinical Outcomes of Percutaneous Nephrolithotomy Following Retrograde Percutaneous Nephrostomy Access Using Novel Device in Comparison to Antegrade Access

The University of Texas System (UT)

Status: Not yet enrolling

Conditions: Kidney Stone

Treatments: Device: antegrade nephrostomy; Device: retrograde nephrostomy

Study type: Interventional

Funder types: Other

Identifiers

NCT05022537

HSC-MS-20-1269

Details and patient eligibility

About

The purpose of this study is to compare relevant clinical outcomes in patients requiring percutaneous nephrostomy for urolithiasis treatment between those who undergo an antegrade approach versus a retrograde approach and to determine which clinical characteristics predict success of lithotomy with anterograde or retrograde percutaneous nephrostomy approaches.

Enrollment: 50 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

-Renal pelvis and proximal ureteral stones >10 mm confirmed with non-contrast computed tomography

Exclusion criteria

• Suspected pyelonephritis.

• Prior percutaneous nephrolithotomy procedure in affected kidney.

• Mid-ureteral or distal ureteral stones.

• Pregnancy.

• Anatomical abnormal kidney, including:

  • Horseshoe
  • Ectopic

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Treatment (retrograde nephrostomy)

Experimental group

Treatment:

Device: retrograde nephrostomy

Control Group ( antegrade nephrostomy)

Active Comparator group

Treatment:

Device: antegrade nephrostomy