Clinical Outcomes of Peroral Endoscopic Myotomy

Asan Medical Center

Status: Unknown

Conditions: Achalasia

Treatments: Other: peroral endoscopic myotomy

Study type: Interventional

Funder types: Other

Identifiers

NCT02989883

2016-0999

Details and patient eligibility

About

Esophageal outflow obstruction is characterized by failure to relax the lower esophageal sphincter (LES), resulting in impaired flow of ingested food into the stomach. The subsequent stasis of ingested food leads to symptoms of dysphagia, regurgitation, chest pain, and weight loss. The core objective of the treatment of esophageal outflow obstruction is to disrupt the LES and reduce its pressure to allow esophageal emptying. Therapeutic options include pharmacologic therapy, Botulinum toxin injection, pneumatic balloon dilation, and surgical myotomy with partial fundoplication. In addition, peroral endoscopy myotomy (POEM) has recently been introduced as a minimally invasive treatment, but there have a few studies regarding long-term outcomes. The aim of this study is to evaluate clinical outcomes of POEM for esophageal outflow obstruction.

Full description

Prospective study

Enrollment: 20 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who were diagnosed as esophageal outflow obstruction
• Patients with informed consent

Exclusion criteria

• Diagnostic uncertainty
• Patients who are not suitable for general anesthesia

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Peroral endoscopic myotomy (POEM)

Other group

Description:

Patients who received POEM

Treatment:

Other: peroral endoscopic myotomy