Clinical Practices for Treating Severe Malaria Caused by P. Falciparum

Centre Hospitalier de Saint-Denis

Status: Completed

Conditions: Drug Therapy, Combination; Malaria, Falciparum; Hospitalization; Retrospective Studies; Plasmodium Falciparum; Treatment Outcome; Antimalarials; Artemisinins

Study type: Observational

Funder types: Other

Identifiers

NCT07027722

0066_SMIT

Details and patient eligibility

About

This study looks at how doctors in three hospitals in France treat patients with a serious form of malaria caused by Plasmodium falciparum. It focuses on cases where the level of malaria parasites in the blood is 4% or higher. The study will compare how often a type of medicine called ACT (artemisinin-based combination therapy) is used on its own instead of the usual first-choice treatment (intravenous artesunate), and whether ACT works just as well. It will also check how well patients recover, whether they have complications, and how long they stay in the hospital.

Enrollment: 77 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients aged 18 years or older.
• Diagnosis of Plasmodium falciparum malaria with a parasitemia level ≥ 4%.

Exclusion criteria

• Patients under 18 years old