Clinical Relevance of Different Training Intensities in Chronic Heart Failure.

Cairo University (CU)

Status: Completed

Conditions: Chronic Heart Failure

Treatments: Other: Aerobic exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT05213546

HF2021

Details and patient eligibility

About

To determine the efficacy of different aerobic exercise training intensities in patients with chronic heart failure.Forty five eligible male patients with chronic heart failure were randomly assigned into three groups( High intensity , moderate intensity and low intensity)groups .

Full description

Forty five eligible male patients with chronic heart failure secondary to ischemic heart disease were selected from National Heart Institute heart failure outpatient clinic , their ages ranged from 50-60 years old and their ejection fraction ranged from 30-40% ,they were randomly assigned into three groups :HIT Group: received High Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months.(n=15) MIT Group: received moderate Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months. .(n=15) LIT Group: received low Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months, Before and after intervention, the following measures were obtained: Echocardiograph parameter (EF%, and left ventricular internal dimension ) , prognostic biomarkers (proBNP), and quality of life .

Enrollment: 45 patients

Sex: Male

Ages: 50 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with following criteria were included :

  • All patients ages were between 50 - 60 years old
  • Fractional shortening < 25% and ejection fraction < 40%
  • Sinus rhythm.
  • Heart Failure due to ischemic heart disease.
  • New York Heart Association (NYHA) class II-III.
  • Regular medical treatment.

Exclusion criteria

• Patients with following criteria were excluded :

  • Chronic heart failure due to other causes
  • History of pulmonary disease (chronic obstructive lung disease, moderate to severe pulmonary hypertension).
  • Recent acute coronary syndrome or revascularization (3 months).
  • Exercise limited by angina or peripheral arterial occlusive disease;
  • Cerebrovascular or musculoskeletal disease preventing exercise testing or training.
  • Poorly controlled or exercise-induced cardiac arrhythmias
  • Logistic problems to attend regular exercise training sessions. Uncontrolled hypertension.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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45 participants in 3 patient groups

High intensity aerobic training group(HIT)

Active Comparator group

Description:

15 patients who received High Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months.

Treatment:

Other: Aerobic exercise training

Moderate intensity aerobic training group(MIT)

Active Comparator group

Description:

15 patients who received moderate Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months.

Treatment:

Other: Aerobic exercise training

Low intensity aerobic training group(LIT)

Active Comparator group

Description:

15 patients who received low Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months

Treatment:

Other: Aerobic exercise training