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About
Rhinovirus (RV) infections represent the most common cause of asthma exacerbations in children and adolescents. The investigators hypothesize that the immune responses generated in the nose of allergic rhinitics and asthmatics underlie subsequent systemic modulation of the immune system, and that - in susceptible individuals (i.e., those with pre-existing asthma) - this modified nasal milieu is responsible for the asthma exacerbation.
Open label single center study in asthmatics as well as allergic rhinitis (AR) and healthy controls. All subjects will undergo good manufacturing practice (GMP) RV16 inoculation and responses will be compared between the 3 cohorts.
Full description
Primary objectives are:
To determine whether RV increases expression of interleukin (IL)-25 transcripts by nasal epithelial cells in the asthma and AR but not control cohorts at the peak of infection (days 3 and 4).
To determine whether RV increases lower respiratory symptoms in the asthma but not AR and control cohorts.
To determine whether asthmatics and allergic rhinitics will demonstrate an increased severity of infection in comparison to control subjects.
Secondary objectives are:
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All subjects:
Allergic Rhinitis Subjects:
Allergic Asthmatic Subjects:
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38 participants in 3 patient groups
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Data sourced from clinicaltrials.gov
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