Clinical Retrospective Study Analysis of Postoperative Complications Following Hepatectomy

Nanfang Hospital, Southern Medical University

Status: Enrolling

Conditions: Liver Failure; Liver Dysfunction

Treatments: Diagnostic Test: International Study Group for Liver Surgery (ISGLS)

Study type: Observational

Funder types: Other

Identifiers

NCT06532214

NFEC-2023-245

Details and patient eligibility

About

Hepatectomy is a crucial surgical method for treating liver diseases such as liver cancer, hepatic hemangiomas, and biliary stones. Although hepatectomy has achieved significant therapeutic effects, postoperative complications remain an inevitable issue. Complications following hepatectomy include liver failure, hepatic vascular thrombosis, wound infection at the hepatic incision, and bile leakage, among others. These complications pose a serious threat to patients' health and life, and also increase the waste of medical resources and the cost of treatment. Currently, research on postoperative complications of hepatectomy mainly focuses on small sample studies from a single center, and most studies only focus on a specific complication, lacking comprehensive and systematic analysis. Therefore, it is necessary to conduct a retrospective study analysis of complications related to hepatectomy to more comprehensively and objectively understand the incidence, risk factors, prevention, and treatment of postoperative complications, providing clinical doctors with more scientific treatment plans and guidance.

Enrollment: 2,000 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Patients aged 18-80 years 2.Patients who underwent liver resection surgery at the participating centers

Exclusion criteria

• Exclusion criteria are as follows:

  1. Prior cancer treatments such as transarterial chemoembolization, ablation, or targeted therapy.
  2. Repeat liver resection surgeries.
  3. Presence of other malignancies.
  4. Concurrent end-stage diseases including active infections, respiratory failure, decompensated heart failure, and autoimmune disease exacerbations.
  5. Inadequate clinical data availability in medical records.

Trial design

2,000 participants in 2 patient groups

PHLF/NPHLF

Description:

PHLF:Post-hepatectomy liver failure,PHLF is commonly diagnosed and classified according to the criteria of the International Study Group for Liver Surgery (ISGLS), utilizing markers of liver function measured on or after postoperative day 5 (POD5). NPHLF:Patients who did not experience liver failure following hepatectomy.

Treatment:

Diagnostic Test: International Study Group for Liver Surgery (ISGLS)

Liver Cirrhosis/No Liver Cirrhosis

Description:

Whether the patient has cirrhosis