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Clinical Significance of Intra-abdominal Hypertension in Surgical Patients With Severe Sepsis

U

University of Ulsan

Status

Completed

Conditions

Leakage
Bowel Perforation
Peritonitis
Pneumonia
Abscess

Study type

Observational

Funder types

Other

Identifiers

NCT01784458
2009-0004

Details and patient eligibility

About

  • Intra-abdominal pressure(IAP) is defined as a steady state pressure of the abdominal cavity
  • many studies have proved IAP as a prognostic factor that elevated IAP influences hemodynamics and multiple organs dysfunction
  • In previous studies, most of them was based on the septic patients of medical diseases. And it is rare about sepsis of surgical diseases such as traumatized or postoperative patients
  • We hypothesized that intra-abdominal hypertension may affect clinical course such as length of stay of intensive care unit, weaning of mechanical ventilation, proceeding of enteral feeding and mortality
  • Our study was aimed to investigate prevalence of IAH and risk factors and to analyze clinical course and prognosis influenced by IAH in surgical patients with severe sepsis

Full description

  • Inclusion criteria older than 18 diagnosed as severe sepsis agreed on informed consent
  • Exclusion criteria refused to participate in the study traumatic injuries on urethra or bladder open abdomen status
  • Definition of severe sepsis organ failure more than one organ with sepsis arterial blood lactate concentration of at least 4mmol/L hypotension with a systolic blood pressure lower than 90mmHg
  • Definition of intra-abdominal hypertension intra-abdominal pressure more than 12mmHg
  • Measurement of IAP measuring via three lument urinary catheter measuring after filling with 25ml normal saline measuring in supine position at level of mid-axillary line on iliac crest measuring three times a day during ICU stay

Enrollment

46 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • older than 18-year
  • agreed on informed consent
  • diagnosed with severe sepsis

Exclusion criteria

  • traumatic injuries on urethra or bladder
  • open abdomen status

Trial design

46 participants in 1 patient group

intra-abdominal hypertension(IAH)
Description:
IAH group : patients developing IAH non-IAH group : patients without IAH

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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