Clinical Significance of Intra-abdominal Hypertension in Surgical Patients With Severe Sepsis

University of Ulsan

Status

Completed

Conditions

Leakage

Bowel Perforation

Peritonitis

Pneumonia

Abscess

Study type

Observational

Funder types

Other

Identifiers

NCT01784458

2009-0004

Details and patient eligibility

About

Intra-abdominal pressure(IAP) is defined as a steady state pressure of the abdominal cavity
many studies have proved IAP as a prognostic factor that elevated IAP influences hemodynamics and multiple organs dysfunction
In previous studies, most of them was based on the septic patients of medical diseases. And it is rare about sepsis of surgical diseases such as traumatized or postoperative patients
We hypothesized that intra-abdominal hypertension may affect clinical course such as length of stay of intensive care unit, weaning of mechanical ventilation, proceeding of enteral feeding and mortality
Our study was aimed to investigate prevalence of IAH and risk factors and to analyze clinical course and prognosis influenced by IAH in surgical patients with severe sepsis

Full description

Inclusion criteria older than 18 diagnosed as severe sepsis agreed on informed consent Exclusion criteria refused to participate in the study traumatic injuries on urethra or bladder open abdomen status Definition of severe sepsis organ failure more than one organ with sepsis arterial blood lactate concentration of at least 4mmol/L hypotension with a systolic blood pressure lower than 90mmHg Definition of intra-abdominal hypertension intra-abdominal pressure more than 12mmHg Measurement of IAP measuring via three lument urinary catheter measuring after filling with 25ml normal saline measuring in supine position at level of mid-axillary line on iliac crest measuring three times a day during ICU stay

Enrollment

46 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria