Clinical Significance of Smear or Culture Positive for Candida Spp. From Sputum Three Times a Week

Capital Medical University

Status and phase

Unknown

Phase 4

Conditions

Pulmonary Candidiasis

Treatments

Drug: fluconazole

Study type

Interventional

Funder types

Other

Identifiers

NCT00537888

CYH-CMU

Details and patient eligibility

About

The definition of pulmonary candidiasis is still unclear.In China, isolation of candida spp. form sputum twice or three times a week has been regarded as the microbiological evidence of pulmonary candidiasis. The investigators hypothesize that patients who present respiratory symptoms and lung infiltrates together with smear of culture positive for candida spp. from sputum three times a week can not be diagnosed as pulmonary candidiasis.

Enrollment

200 estimated patients

Sex

All

Ages

14 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

85ys>age>14ys
APACHE II<25
Lung infiltrates together with at least one of the following symptoms:cough, sputum, dyspnea with or without fever
smear or culture positive for candida spp. from sputum

Exclusion criteria

Pregnancy
Hypersensitivity to fluconazole
Isolated candida was non-sensitive to fluconazole
Severe liver or renal diseases who can not tolerate fluconazole treatment
With at least one of the following high risk factors:organ transplantation, neutropenia>10ds, long term glucocorticoids therapy(equal to prednisone 30mg/d longer than 2 weeks), immunosuppressive therapy within 30ds, AIDS
With one of the microbiological evidence:isolation of candida spp. from blood or other kinds of sterile site(not including urine), filamentous fungi isolated from sputum or BALF, cryptococcus isolated from sputum or CSF, galactomannan antigen positive twice for blood
Probable or possible pulmonary aspergillosis
Definite oral or esophageal candidiasis