Clinical Significance of Supranormal Differential Renal Function in the Recovery of Hydronephrosis

Seoul National University

Status: Completed

Conditions: Hydronephrosis

Treatments: Procedure: dismembered pyeloplasty

Study type: Observational

Funder types: Other

Identifiers

NCT01839006

supranormal

supranormal DRF

Details and patient eligibility

About

The purpose of this study is to assess the clinical significance of supranormal differential renal function (DRF) in the recovery of unilateral hydronephrosis (HN) after surgery, pediatric patients who underwent pyeloplasty for ureteropelvic junction obstruction (UPJO) who showed supranormal DRF (> 55%) in the DTPA renography will be analyzed.

Full description

To assess the clinical significance of supranormal differential renal function (DRF) in the recovery of unilateral hydronephrosis (HN) after surgery, pediatric patients who underwent pyeloplasty for ureteropelvic junction obstruction (UPJO) who showed supranormal DRF (> 55%) in the DTPA renography will be analyzed. Clinical parameters including age at the first visit, age at operation, gender, laterality, and follow-up period will be evaluated. To evaluate predictors of recovery from supranormal renal function according to the level of DRF, univariate and multivariate logistic regression analyses will be performed. Patients would be subcategorized into two groups; group A (DRF ≤60%) and group B (DRF >60%) in consideration of the mean value of preoperative DRF and each parameter of group A was compared to that of group B using independent sample's t test and chi square test. Kaplan-Meier analysis and log-rank test will be used to determine the difference of recovery time of obstructed hydronephrosis in each parameter.

Enrollment: 34 patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ureteropelvic junction obstruction
• hydronephrosis
• differential renal function more than 55% in DTPA
• follow-up period more than 1 year

Exclusion criteria

• urological anomalies, such as vesicoureteral reflux, ureterocele, cystic kidney disease, posterior urethral valves, duplex anomalies, neurogenic bladder, and solitary kidney or patients who underwent any previous urological surgery

Trial design

34 participants in 1 patient group

patients with supranormal renal function

Description:

Patients with preoperative HN and supranormal renal function in DTPA renography

Treatment:

Procedure: dismembered pyeloplasty