Clinical Study of Acupoint Application on Relieving qi Deficiency and Constipation in Patients Undergoing Chemotherapy

Zhejiang University

Status: Enrolling

Conditions: Chemotherapy; Postoperative Chemotherapy

Treatments: Behavioral: Routine treatment and nursing of constipation; Drug: Acupoint application

Study type: Interventional

Funder types: Other

Identifiers

NCT07276932

2025-0322

Details and patient eligibility

About

4.1 Research Content

1. Clarifying the acupoint application scheme for deficiency and constipation in CRC patients undergoing chemotherapy: the preliminary acupoint application scheme for deficiency and constipation in CRC patients was formulated according to the systematic literature search, analysis of acupoint and traditional Chinese medicine prescription, analysis of meridian tropism of acupoints, Chinese herbal medicine taste and meridian tropism, etc., and multidisciplinary expert consultation. Through two rounds of Delphi expert letter consultation, the acupoint application scheme for deficiency and secret of CRC patients undergoing chemotherapy was determined.
2. Randomized controlled trials were conducted to compare the effect of acupoint application scheme and conventional treatment in improving constipation symptoms, total clinical efficacy, and improving patient comfort rate in CRC patients undergoing chemotherapy.

4.2 Key problems to be solved Based on the theory of "state-target dialectics", the analysis of acupoints and traditional Chinese medicine prescriptions, the analysis of meridian tropism of acupoints, the flavor and meridian tropism of Chinese herbs are used to select Chinese herbs that moisten the intestine and relieve defecation, strengthen the central and qi, and explore the acupoint application to provide a basis for more effective application of acupoint application in the treatment of qi deficiency and constipation in patients with CRC chemotherapy, form a generalized integrated Chinese and western medicine diagnosis and treatment plan, and promote the development of integrated Chinese and western medicine.

4.3 Expected Goals

1. Clarify the diagnosis and treatment plan of acupoint application in the treatment of qi deficiency and constipation in patients with colorectal cancer.
2. The flexible application of classic formula and scientific acupoint selection and sticking can effectively relieve qi deficiency and constipation in CRC patients undergoing chemotherapy, improve the total clinical efficacy and comfort of patients. It has been used in clinical practice and promoted to other medical institutions.

Enrollment: 106 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Clinical diagnosis of colorectal cancer
2. Chemotherapy was performed after surgery
3. Diagnosis of qi deficiency and constipation
4. Age ≥18 years old

Exclusion criteria

1. Clinical diagnosis of other digestive tract or anal organic diseases
2. Observed with severe cardiac, hepatic, renal insufficiency or other complications
3. Allergic constitution or allergy to a drug in constipation paste

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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106 participants in 2 patient groups

Acupoint application + conventional treatment and nursing program

Experimental group

Treatment:

Drug: Acupoint application

Behavioral: Routine treatment and nursing of constipation

Routine treatment and nursing of constipation

Active Comparator group

Treatment:

Behavioral: Routine treatment and nursing of constipation