Clinical Study of Angong Niuhuang Pill and Acupuncture on PSCI Angong Niuhuang Pill Combined With Supervised Pulse Music Electroacupuncture on Cognitive Impairment After Ischemic Stroke

Zhejiang University

Status and phase: Enrolling; Early Phase 1

Conditions: Post-stroke Cognitive Impairment

Treatments: Drug: Angong Niuhuang Pill

Study type: Interventional

Funder types: Other

Identifiers

NCT05731310

2022-0507

Details and patient eligibility

About

Post stroke cognitive impairment (PSCI) refers to the attainment of cognitive impairment after the clinical event of stroke A range of syndromes that impede diagnostic criteria. Epidemiologically, PSCI is one of the common complications in stroke patients

Full description

(1) Clinical scale data of cognitive function, daily living ability of PSCI patients integrated with the research of this project using uterine Niu Huang pill combined with examined pulse music electroacupuncture

For analysis, the efficacy of PSCI patients was observed; (2) In depth studies on auditory event-related potentials of PSCI treated by uterine Niu Huang pill combined with examined pulse music electroacupuncture

The changes of serum related nerve growth factor and the relationship between each other in order to enrich / fill our province's research results in this field; (3) In key academic journals

1 high level scientific research paper published.

Enrollment: 65 estimated patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

(1) All were the first stroke, confirmed by head computed tomography (CT) or magnetic resonance imaging (MRI), with vital signs

stable; (2) Those who are conscious and can cooperate with relevant treatment; (3) Montreal Cognitive Assessment Scale (MoCA) score ≤ 24 points; （4）

The course of disease is more than 1 month, and the patient is 40-70 years old.

Exclusion criteria

(1) People with cognitive impairment before onset; (2) There are contraindications of Angong Niuhuang Pill or electroacupuncture treatment;

(3) Complicated with dysfunction of heart, liver, kidney and other important organs; (4) Previous history of cerebral hemorrhage, epilepsy, brain injury, etc; (5) Before onset

Have a history of alcohol and drug dependence; (6) The condition worsens, and new hemorrhagic or infarcted foci appear.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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65 participants in 3 patient groups

Angong Niuhuang Pill Group

Experimental group

Description:

Take half an Angong Niuhuang pill every day for 4 weeks

Treatment:

Drug: Angong Niuhuang Pill

Angong Niuhuang pill combined with music electroacupuncture group

Experimental group

Description:

Take half an Angong Niuhuang pill every day for 4 weeks and Daily music scalp acupuncture treatment

Treatment:

Drug: Angong Niuhuang Pill

General control group

No Intervention group

Description:

no intervention