Clinical Study of Curcumin in Preventing Postoperative Adhesion of Bilateral Vocal Cords

Eye & ENT Hospital of Fudan University

Status and phase: Enrolling; Phase 2; Phase 1

Conditions: Laryngeal Leucoplakia; Laryngeal Polyp; Laryngeal Papilloma; Glottic Carcinoma; Glottic Web of Larynx; Laryngeal Stenosis

Treatments: Drug: Curcumin; Drug: Mitomycin-C

Study type: Interventional

Funder types: Other

Identifiers

NCT05688488

2022011-1

Details and patient eligibility

About

To provide a novel therapy idea and method to solve the clinical problem of postoperative adhesion of bilateral vocal cords, patients enrolled in this study will be applied with curcumin on both wound sites of bilateral vocal cords after the surgery on the bilateral vocal cord endoscopically.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with bilateral vocal cord diseases who are going to undergo resection of bilateral vocal cord lesions endoscopically.
2. Patients with bilateral vocal cord adhesion who are going to undergo incision of bilateral vocal cord adhesion endoscopically.

Exclusion criteria

1. Patients with other laryngeal diseases.
2. Patients with cardiac and pulmonary insufficiency.
3. Patients unable to cooperate with the follow-up on time after surgery.
4. Patients who refuse to sign the informed consent after notification.
5. Patients who have a severe allergic disease or allergic history to a variety of drugs.
6. Other circumstances that are not appropriate to be included in the clinical trial.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

100 participants in 2 patient groups

Curcumin

Experimental group

Treatment:

Drug: Curcumin

Mitomycin

Active Comparator group

Treatment:

Drug: Mitomycin-C