Clinical Study of Fecal Microbiota Transplantation in the Treatment of Antibiotic-associated Diarrhea

Tongji University

Status: Completed

Conditions: Antibiotic-associated Diarrhea; Fecal Microbiota Transplantation

Treatments: Procedure: Fecal Microbiota Transplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT05990972

FMT-AAD

Details and patient eligibility

About

Antibiotic-associated diarrhea (AAD) refers to the occurrence of other unexplained diarrhea symptoms after the use of antibiotics, often combined with abdominal pain, bloating and bloody stool. Fecal Microbiota Transplantation (FMT) is a therapeutic method to transplant the microbiota from the feces of healthy people into the intestinal tract of patients. To explore the overall efficacy and safety of FMT in the treatment of AAD.

Enrollment: 25 patients

Sex: All

Ages: 21 to 78 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• occurrence of antibiotic-associated diarrhoea; no response to standard therapy; agree to receive FMT and sign informed consent; willingness to provide stool samples.

Exclusion criteria

• non-antibiotic-associated diarrhea; did not accept FMT or did not sign informed consent; unwillingness to provide stool samples.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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25 participants in 1 patient group

FMT group

Experimental group

Treatment:

Procedure: Fecal Microbiota Transplantation