Clinical Study of Intestinal Barrier Dysfunction After Gastrointestinal Surgery

Kunming Medical University

Status

Not yet enrolling

Conditions

Intestinal Barrier Dysfunction

Treatments

Other: No intervention was carried out

Study type

Observational

Funder types

Other

Identifiers

NCT06596070

PJ-2024-124

Details and patient eligibility

About

The goal of this observational study is to explore the clinical influences associated with the development of intestinal barrier dysfunction in patients undergoing gastrointestinal surgery. The main question it aims to answer is:What clinical factors increase the probability of developing intestinal barrier dysfunction in patients after gastrointestinal surgery?

Enrollment

180 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

men or women aged 18-80 years
expected feasible abdominal surgical treatment (partial gastrectomy, colorectal resection)
no preoperative intestinal barrier dysfunction
patients voluntarily participated in this study and signed an informed consent form.

Exclusion criteria

Patients or their families refused to participate in this study
chronic inflammatory diseases (e.g. inflammatory bowel disease, chronic hepatitis, chronic pancreatitis, chronic peptic ulcer, etc.)
history of antibiotic administration in the last 2 weeks
severe cognitive impairment and other inability to cooperate preoperative neoadjuvant radiotherapy
combined with severe hepatic, renal, and cardiac insufficiency patients.