Clinical Study of Pain Reduction by Peri-arthroscopic PRP Application in Knee Degeneration (PRP-Bochum)

Ruhr University of Bochum

Status and phase: Completed; Phase 4

Conditions: Cartilage Damage; Meniscal Tear; Knee Osteoarthritis

Treatments: Biological: Platelet rich plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT02189408

PRP-Bochum

Details and patient eligibility

About

The purpose of this study is to investigate reduction of pain, gain of function and improvement of life quality by intraoperative applied platelet- rich- plasma ( PRP ) during knee arthroscopy for degeneration and osteoarthritis OA by conducting a randomized- controlled, double-blinded trial ( RCT ) including 58 patients with a follow up of 12 months and pain, assessed by Visual- Analogue Scale (VAS) after 6 months as primary endpoint.

Enrollment: 58 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• degenerative knee pain
• age: > 18 years
• informed consent
• none to moderate comorbidity
• arthroscopy under general anaesthesia indicated

Exclusion criteria

• trauma of the knee within the last 6 weeks before surgery
• circumscribed cartilage lesion with possibility of repair microfracture or autologous chondrocyte transplantation - procedures
• contraindications against PRP. application
• malignancies
• severe comorbidities
• age <18 years
• physically or mentally not able to provide informed consent
• severe knee instability
• corticosteroid injections within the last 6 weeks before surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

58 participants in 2 patient groups

PRP

Experimental group

Description:

one intraoperative application of PRP in the interventional group

Treatment:

Biological: Platelet rich plasma

Control

No Intervention group

Description:

No application of any substance during knee arthroscopy