Clinical Study on Endometrial Receptivity

Chinese Academy of Medical Sciences & Peking Union Medical College

Status and phase: Unknown; Early Phase 1

Conditions: Endometrial Receptivity;RNA; Progesterone

Treatments: Drug: Progesterone

Study type: Interventional

Funder types: Other

Identifiers

NCT03687021

yuqi03029

Details and patient eligibility

About

to explore the differential expression of miRNA in the implantation window of patients with endometriosis and the time of progesterone and route of administration on planting window

Enrollment: 35 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. The endometriosis group treatment group: Previous laparoscopy or laparotomy confirmed endometriosis;Regular menstruation, no rule vaginal bleeding;Ovarian reserve function is normal.

   control group: Laparoscopic bilateral salpingectomy was performed due to ectopic pregnancy, benign ovarian changes and other reasons, with the exception of endometriosis during the operation.Regular menstruation, no rule vaginal bleeding;Ovarian reserve function is normal

2. progesterone group Women with hypothalamic amenorrhea or premature ovarian failure;Ages 18-40

Exclusion criteria

Patients with medical complications

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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35 participants in 5 patient groups

endometriosis

No Intervention group

Description:

tissue biopsy from patients (n=10) with endometriosis

without endometriosis

No Intervention group

Description:

tissue biopsy from patients (n=10) without endometriosis

Intramuscular progesterone

Experimental group

Description:

Intramuscular progestin(20mg)

Treatment:

Drug: Progesterone

vaginal progesterone

Experimental group

Description:

vaginal progestin (90mg)

Treatment:

Drug: Progesterone

oral progesterone

Experimental group

Description:

oral progestin(40mg)

Treatment:

Drug: Progesterone