Clinical Trail of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Upper Limb Bradykinesia in Parkinson' Disease' Patients

Shanghai Jiao Tong University

Status: Invitation-only

Conditions: Bradykinesia; Parkinson's Disease (PD); Upper Limb Function

Treatments: Device: high frequency-repetitive transcranial magnetic stimulation; Device: sham stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT06641193

XHEC-C-2024-125-2-2

Details and patient eligibility

About

A randomized, double-blind, sham-controlled unicenter clinical trial was used to investigate the effectiveness and neural mechanism of high-frequency repetitive transcranial magnetic stimulation in the treatment of upper limb bradykinesia in patients with Parkinson's disease.

Enrollment: 60 estimated patients

Sex: All

Ages: 50 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hoehn and Yahr (HY) stage 1-2
• Able to understand and cooperate with the study
• Predominantly characterized by bradykinesia
• Onset on the left side

Exclusion criteria

• Contraindications for TMS including DBS surgery, Ventriculoperitoneal shunt, etc
• Other neurological disorders
• Significant resting tremor, with MDS-UPDRS-III tremor score ≥3
• Resting threshold cannot be measured
• Received other TMS treatments within the last 3 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

verum group

Experimental group

Description:

verum group receive real 10 sessions of rTMS stimulation. once daily for 5 consecutive days a week.

Treatment:

Device: high frequency-repetitive transcranial magnetic stimulation

sham group

Sham Comparator group

Description:

The sham group receives 10 sessions of rTMS stimulation, once daily for 5 consecutive days a week. However, a sham stimulation coil is used, which emits the same sound and vibration as the active coil but does not produce any induced electrical currents.

Treatment:

Device: sham stimulation