Clinical Trial Comparing Continuous Versus Intermittent Hemodialysis in ICU Patients (CONVINT)

Charité University Medicine Berlin

Status and phase: Completed; Phase 3; Phase 2

Conditions: Acute Renal Failure

Treatments: Other: RRT for acute kidney failure using the IHD (intermittent HD); Other: RRT for acute kidney failure using the CVVH method

Study type: Interventional

Funder types: Other

Identifiers

NCT01228123

CONVINT

Details and patient eligibility

About

The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e. intermittent haemodialysis (IHD) or continuous haemofiltration (CVVH), might impact on the outcome of these patients. For this purpose, a prospective randomised clinical study of the effect of continuous versus intermittent renal replacement therapy on the mortality and outcome of acute renal failure will be performed.

Full description

please see above

Enrollment: 252 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all ICU patients requiring renal replacement therapy

Exclusion criteria

• patient denies informed consent
• patient not requiring intensive care therapy
• kidney transplanted patients
• chronic renal failure (serum creatinine > 3mg/dl)

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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252 participants in 2 patient groups

CVVH arm

Active Comparator group

Treatment:

Other: RRT for acute kidney failure using the CVVH method

IHD arm

Active Comparator group

Treatment:

Other: RRT for acute kidney failure using the IHD (intermittent HD)