Clinical Trial For The Treatment Of Chronic Chagas Disease With Posaconazole And Benznidazole (CHAGASAZOL)

Vall d'Hebron University Hospital (HUVH)

Status and phase: Completed; Phase 2

Conditions: Chagas Disease

Treatments: Drug: Benznidazole; Drug: Posaconazole

Study type: Interventional

Funder types: Other

Identifiers

NCT01162967

CHAGASAZOL01

Details and patient eligibility

About

The investigators propose the evaluation of posaconazole and benznidazole in humans for the treatment of Chagas disease chronical infection. Exploratory trial of posaconazole antiparasitic activity against Trypanosoma cruzi.

Enrollment: 78 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Consenting patients with serological evidence of Chagas infection and positive PCR real time

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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78 participants in 3 patient groups

Benznidazole

Active Comparator group

Treatment:

Drug: Benznidazole

Posaconazole, low dose

Experimental group

Treatment:

Drug: Posaconazole

Posaconazole, high dose

Experimental group

Treatment:

Drug: Posaconazole