Clinical Trial on the Efficacy of Intralesional Triamcinolone Versus Candida Albicans Antigen in Treating Alopecia Areata

Universidad Autonoma de Nuevo Leon

Status

Enrolling

Conditions

Alopecia Areata

Treatments

Drug: Candida Albicans Antigen Injection

Study type

Interventional

Funder types

Other

Identifiers

NCT06564805

DE24-00008

Details and patient eligibility

About

The efficacy of two intralesional treatment modalities for alopecia areata will be determined. Thirty patients over the age of 6 with the diagnosis of alopecia areata on the scalp, with an extension of less than 50%, will be included. A comparison will be made between the effectiveness of intralesional Triamcinolone (standard first-line treatment) and intralesional Candida albicans antigen, with serial clinical and trichoscopic pictures at follow-up to evaluate the clinical response and associated adverse effects.

Enrollment

30 estimated patients

Sex

All

Ages

6+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosis of alopecia areata
SALT score of less than 50% extension
Has not received any topical or systemic treatment in the last month
Signed informed consent

Exclusion criteria

Any skin condition on the scalp (infectious, inflammatory or neoplastic) that could modify the clinical of trichoscopic features
Pregnancy or breast-feeding
Patients in medications that could cause hair loss as side-effects

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

30 participants in 2 patient groups

intralesional Triamcinolone

Active Comparator group

Description:

Triamcinolone acetonide will be administered intralesionally at a concentration of 4 mg/mL. The solution will be injected in 0.1 mL doses, spaced 1 cm apart. The maximum total dose per session will be limited to 3 mL

Treatment:

Drug: Candida Albicans Antigen Injection

Candida albicans antigen

Experimental group

Description:

Single subcutaneous administration of 0.1 mL of Candida albicans antigen into one of the alopecic patches

Treatment:

Drug: Candida Albicans Antigen Injection