Clinical Trial Study About Human Adipose-Derived Stem Cells in the Liver Cirrhosis

Gwo Xi Stem Cell Applied Technology

Status and phase: Completed; Phase 1

Conditions: Liver Cirrhosis

Treatments: Drug: ADSCs

Study type: Interventional

Funder types: Industry

Identifiers

NCT02297867

28113265

Details and patient eligibility

About

The aim of the investigators study was to investigate the safety and efficacy of autologous ADSCs for the clinical treatment of liver cirrhosis.

Full description

One milliliter of cell suspension will be injected intrahepatically under sonographic guidance using a gauge-18 needle.

Enrollment: 6 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Liver cirrhosis investigators with age 20 to 80 years (both inclusive).
2. Investigators without Mandatory Communicable Disease (HBV, HCV, HIV, syphilis)
3. Investigators without rare disorder
4. Coagulation normalities
5. Investigators without autoimmune disorder
6. Investigators without Acquired Immune Deficiency Syndrome
7. Investigators without cancer
8. Investigators BMI > 15

Exclusion criteria

1. Pregnant women
2. Investigators with acute stroke in one month and unconsciousness
3. Investigators with acute myocardial infarction or acute heart failure
4. Investigators with serious liver dysfunction and coagulation dysfunction and ascites mild higher
5. Investigators with acute respiratory failure or pneumonia
6. Kidney Failure: BUN > 50
7. Anemia: Hematocrit < 25
8. Investigators diagnosed with liver cancer or liver metastatic carcinoma
9. Investigators with liver abscess
10. Investigators with acute Hepatitis
11. Investigators with acute infective
12. Liver cirrhosis patients with HBV or HCV
13. Investigators diagnosed with carcinoma and receiving treatment
14. Investigators with Schizophrenia or melancholia
15. Investigators received serious surgical operations in 3 months
16. Investigators unable to control hypertension (SBP > 180 mmHg, DBP > 110 mmHg) or diabetes (AC sugar > 200 mg/dl)
17. Others can't fit into the trial evaluate by investigator

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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6 participants in 1 patient group

ADSCs

Experimental group

Description:

One milliliter of cell suspension will be injected intrahepatically under sonographic guidance using a gauge-18 needle.

Treatment:

Drug: ADSCs