Clinical Value of DWI-ADC Matching in the Short-term Prognosis of Wilson's Disease

Hospital Affiliated to the Institute of Neurology, Anhui University of Chinese Medicine

Status: Not yet enrolling

Conditions: Hepatolenticular Degeneration; Wilson

Study type: Observational

Funder types: Other

Identifiers

NCT06196931

AHnkyy20231020

Details and patient eligibility

About

In earlier studies, it was found that patients of Wilson disease with new diagnosed who only has neurological symptoms often had DWI hyper-intensity in brain MRI, which was more common in putamen and midbrain, indicating that the disease was in the acute stage. However, many patients had ADC hyper-intensity or hypo-intensity at the same time, and the two different signals represented different disease processes from an imaging perspective. The former indicating T2 penetration effect, and the latter represents diffusion limitation, which indicating the presence of local inflammation, edema, etc. Whether the signal changes of these two different matching modes have guiding significance for the early de-copper treatment for WD, one is the core point of our study. We hope to exploring the predictive value about DWI-ACD signal matching for symptoms changes in the earlier time of de-copper treatment through this study.

Enrollment: 200 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. Patients had been previously diagnosed with WD who both had DWI hyper-intensity and ADC hyper-intensity or hypo-intensity at the same time；

2. Patients who accept de-copper treatment in hospitalization for 4 weeks or more.

   Exclusion Criteria:

   1. Patients who only with liver injury;
   2. Severe complications;

3. Combined with other diseases.