Clinical Value of Left Atrial Appendage Flow for Prediction of Successful Catheter Ablation for Persistent Atrial Fibrillation (CLAAAF)

Clinique Pasteur

Status: Terminated

Conditions: Persistent Atrial Fibrillation; Catheter Ablation

Treatments: Other: a complete transesophageal echocardiography

Study type: Observational

Funder types: Other

Identifiers

NCT01144858

past-1001-ryth

Details and patient eligibility

About

The purpose of this study was to determine whether left atrial appendage flow velocity, as determined using trans esophageal echocardiography (TEE), predicts the outcome after catheter ablation of persistent Atrial fibrillation( pAF).

Full description

40 PAF patients underwent 3D mapping and ablation. A stepwise approach including circumferential pulmonary vein (PV) isolation, continuous complex-fractionated electrogram (CFE) ablation and linear ablation was performed by the same operator. The procedural end point was termination of persistent AF by catheter ablation, either by conversion directly to sinus rhythm or to atrial tachycardia. Left atrial appendage (LAA) peak flow velocities were measured with transesophageal echography and averaged within each RR interval of 10 consecutive cardiac cycles.

Enrollment: 40 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• First-time radiofrequency catheter ablation for pAF. pAF was defined as continuous AF lasting longer than 1 month, resistant to either electrical or pharmacological cardioversion.
• Informed consent

Exclusion criteria

• Severe valvular disease requiring surgery
• Valvular prosthesis
• Known severe coronary artery disease
• Atrial and/or ventricular thrombosis
• New York Heart Association functional class III to IV
• Cerebrovascular disease
• Pulmonary embolism
• Latent or manifest hyperthyroidism

Trial design

40 participants in 1 patient group

patients with persistent atrial fibrillation ablation

Treatment:

Other: a complete transesophageal echocardiography