Clinical Value of Remote Ischemic Preconditioning

Norwegian University of Science and Technology

Status: Completed

Conditions: Atrial Fibrillation; Heart Diseases

Treatments: Procedure: RIPC

Study type: Interventional

Funder types: Other

Identifiers

NCT01740102

2011/2525

Details and patient eligibility

About

Objectives: Despite utilization of available means for cardioprotection during cardiac surgery, myocardial injury still occurs. Further improvement of cardioprotection is therefore necessary. Remote ischemic preconditioning (RIPC) is an easy and non-invasive method. Laboratory research has shown promising results regarding myocardial survival during open heart surgery, but the clinical value of RIPC is still largely unknown. The investigators hypothesize that RIPC before coronary artery bypass grafting (CABG) reduces the incidence of postoperative atrial fibrillation (POAF).

Enrollment: 92 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elective isolated on-pump CABG surgery
• Informed consent

Exclusion criteria

• Patients with a severe pulmonary disease
• Patients with renal failure (GFR<30 mL/min/1.73 m2)
• Patients with liver failure
• Peripheral vascular disease affecting the upper limbs
• Patients on sulfonylurea derivatives.
• Patients with atrial fibrillation in their case history
• Prior cardiac surgery (Re-operations)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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92 participants in 2 patient groups

RIPC

Experimental group

Description:

Remote ischemic preconditioning (RIPC) in the operating theatre after induction of anaesthesia and before surgery.

Treatment:

Procedure: RIPC

No RIPC

No Intervention group

Description:

Patients in the control group will not receive remote ischemic preconditioning before the surgery.