Clinico-immunological Characterization and Immune Tolerance Breakdown in HU-autoimmunity (CarTo-Hu)

Civil Hospices of Lyon

Status: Active, not recruiting

Conditions: Immune Tolerance

Treatments: Other: Description of clinical, immunological and tumor features of patients harboring Hu Abs

Study type: Observational

Funder types: Other

Identifiers

NCT05745792

751

Details and patient eligibility

About

Phenotypic characterization of patients with Hu-Abs, including the different neurological presentation and the presence or not of an underlying cancer.

Analysis and clinical correlation of the diagnostic techniques for Hu-Abs detection (immunofluorescence, immunodot/Western blot, and CBA) in serum and/or CSF.

Genomic and transcriptomic features of tumors (histological and immune infiltrate characteristics, transcriptomic profile, mutational status).

Enrollment: 400 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• Inclusion Criteria * :

  • Patient with neurological disorder
  • Patient with Hu antibody in sera or CSF

• Exclusion Criteria * :

  • Patient with no data
  • Patient without neurological disorder
  • Patient without Hu antibody in sera/CSF

Trial design

400 participants in 1 patient group

Patients with Hu Abs

Description:

Patients harboring Hu Abs and a neurological syndrome

Treatment:

Other: Description of clinical, immunological and tumor features of patients harboring Hu Abs