Clinicopathologic and Ancillary Testing of Primary Clear Cell Carcinoma of the Cervix

M.D. Anderson Cancer Center

Status: Enrolling

Conditions: Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type

Treatments: Other: Electronic Health Record Review; Other: Laboratory Biomarker Analysis

Study type: Observational

Funder types: Other

Identifiers

NCT05046080

NCI-2021-08814 (Registry Identifier)

2020-0989 (Other Identifier)

Details and patient eligibility

About

This study aims to provide a comprehensive report on clinicopathologic features, immunohistochemical/biomarker testing and molecular profile of cervical clear cell carcinoma. This study may help researchers learn more about the molecular profile of cervical clear cell carcinoma.

Full description

PRIMARY OBJECTIVE:

I. To perform a retrospective clinicopathologic study on patients diagnosed and treated for clear cell carcinoma of the cervix at M D Anderson Cancer Center (MDACC) and to delineate the immunohistochemical and molecular profile of these cases.

OUTLINE:

Patients' medical records are reviewed retrospectively, and archival tumor tissue analyzed by immunohistochemistry and next generation sequencing.

Enrollment: 70 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients diagnosed with clear cell carcinoma of the cervix at MDACC

Trial design

70 participants in 1 patient group

Observational (medical record review)

Description:

Patients' medical records are reviewed retrospectively, and archival tumor tissue analyzed by immunohistochemistry and next generation sequencing.

Treatment:

Other: Laboratory Biomarker Analysis

Other: Electronic Health Record Review