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In this study the investigators will link brain iron levels obtained from quantitative susceptibility maps of HD patients with specific and well-known clinical CSF markers for iron accumulation, neurodegeneration and neuroinflammation. The relationship between iron accumulation and neuroinflammation, and the clinical and genetic characteristics of HD will be investigated. This will provide an important basis for the evaluation of brain iron levels as an imaging biomarker for disease state in HD and their relationship with the salient pathomechanisms of the disease.
Full description
This investigator-initiated, single-site cross-sectional study looks at iron accumulation using 7T MR-imaging, CSF and blood. This will be achieved in a two-day visit involving clinical assessments, MRI-scanning of the brain, followed by a lumbar puncture the next day, after overnight fasting. Sixty-five volunteers with HD and 25 volunteers without HD will be included. Of these 65 volunteers with HD, 25 will be premanifest, 20 early manifest and 20 moderate manifest, in order to cover the wide-spectrum of Huntington's Disease.
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Inclusion criteria
And in addition:
If the participant is a pre-manifest HD gene carrier:
If the participant is an early-manifest HD gene carrier:
If the participant is a moderate manifest HD gene carrier:
If the participant is a control subject:
Exclusion criteria
Additional major comorbidities not related to HD (e.g. cardiovascular diseases, coagulopathy, hypertension, diabetes mellitus, and/or other neurological disorders);
History of severe head injury;
Status of the participant after brain surgery;
Past erythrocyte transfusions;
Use of investigational drugs or participation in a clinical drug trial within 30 days prior to study visit;
Current intoxication, drug or alcohol abuse or dependence;
Pregnancy;
Inability to understand the information about the protocol;
Severe physical restrictions (completely wheelchair dependent);
Severe chorea that, in the investigator's judgment, precludes the patient's participation in and completion of the MRI and/or lumbar puncture.
Contra-indication to MRI scanning, such as:
Contraindications for a lumbar puncture, including:
90 participants in 4 patient groups
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Central trial contact
Nadine van de Zande, MD; Kasper van der Zwaan, drs
Data sourced from clinicaltrials.gov
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