cliniMACs HUD for T Cell Depletion

University of Miami

Status

Conditions: x Linked Combined Immunodeficiency

Treatments: Device: CliniMACs

Study type: Expanded Access

Funder types: Other

Identifiers

NCT02915406

20160472

Details and patient eligibility

About

This protocol is designed to enable access to related or unrelated CD34 cells manufactured using the CliniMACS (Miltenyi) under the HUD designation for patients needing T cell depleted allogeneic grafts for hematopoietic stem cell transplant (HSCT). This will include patients with inherited immunodeficiency disorders as well as patients with malignancies, bone marrow failure, and other rare diseases amenable to HSCT. Finally, patients with poor graft function and Graft Versus Host Disease(GVHD) after a previous HSCT may require a boost of T-cell depleted donor Peripheral Blood Stem Cell (PBSCs) or bone marrow cells that are CD34 selected using the CliniMACS device ENROLLMENT BY INVITATION ONLY

Sex: All

Ages: Under 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

severe combined immune deficiency need for stem cell boost

Exclusion criteria

n/a