Clomiphene Citrate in Infertile Men With Idiopathic Oligoasthenozoospermia

Shakeela Ishrat

Status and phase

Completed

Phase 3

Conditions

Infertility, Male

Treatments

Drug: Clomiphene Citrate

Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT06564961

4068

Details and patient eligibility

About

The goal of this clinical trial is to learn if drug clomiphene citrate improves sperm parameters in infertile men with idiopathic oligoasthenozoospermia. It will also learn about the safety of clomiphene citrate. The main questions it aims to answer are:

Does drug clomiphene citrate change sperm count and motility in infertile men with idiopathic oligoasthenozoospermia?
What medical problems do participants have when taking drug clomiphene citrate? Researchers will compare drug clomiphene citrate to a placebo (a look-alike substance that contains no drug) to see if drug clomiphene citrate works to treat idiopathic oligoasthenozoospermia.

Enrollment

50 patients

Sex

Male

Ages

25 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Infertile men
Idiopathic oligoasthenozoospermia (serum FSH and serum LH range was 2-7 IU/mL and serum testosterone level was >300 ng/dl)

Exclusion criteria

Azoospermia
Body mass index <18 kg/m2 and >30 kg/m2
Any abnormality on genital examination and scrotal sonogram
History of genital diseases & genital surgery
Medical and endocrine disorders like uncontrolled diabetes mellitus, severe kidney disease and liver insufficiency
Psycho-sexual abnormalities
Antioxidant supplements in previous 3 months
Smoking, drug, alcohol or substance abuse
History of chemotherapy or radiotherapy
Presence of any gross female factor abnormality