Clonal Hematopoiesis of Indeterminate Potential in Venous Thromboembolism (CHIPS)

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Venous Thromboembolism

Study type: Observational

Funder types: Other

Identifiers

NCT04477564

NIMAO/2020-01/SB-01

Details and patient eligibility

About

The aim of the study is to investigate the existence of clonal hematopoiesis of indeterminate potential (CHIP) in patients with a history of venous thromboembolism.

The study investigators make the assumption that these patients present mutations involved in CHIP occurrence.

Enrollment: 150 patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men and women over 50 years old who have consulted at the Hematology laboratory of the Nîmes University Hospital for the occurrence or history of venous thromboembolism
• Patient who has accepted that their DNA was kept and used in the context of research on venous thromboembolism (biobank (registration number DC-2008-290 and authorization number AC-2008-107))

Exclusion criteria

• Patients less than 50 years old
• Patient who has refused that their DNA was kept and used in the context of research on venous thromboembolism

Trial design

150 participants in 3 patient groups

Unprovoked proximal deep vein thrombosis

Provoked distal deep vein thrombosis

age-matched control group with no history of vein thrombosis