Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers (Remiclon)

University of Oslo (UIO)

Status and phase: Completed; Phase 2; Phase 1

Conditions: Respiration; Sedation; Acute Pain

Treatments: Drug: Remifentanil+clonidine

Study type: Interventional

Funder types: Other

Identifiers

NCT00730054

S-03025

Details and patient eligibility

About

The hypothesis is that systemic remifentanil and Clonidine act in a synergistic manner to relief acute main in an experimental human pain model. Of interest is also the effect of the combination on respiration, sedation and cognitive behavior.

Full description

To examine the possible synergistic effects og systemic remifentanil and clonidine. Its effects on respiration, cognitive function and sedation.

Enrollment: 12 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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12 participants in 4 patient groups, including a placebo group

1

Active Comparator group

Description:

Clonidine

Treatment:

Drug: Remifentanil+clonidine

2

Active Comparator group

Description:

Remifentanil

Treatment:

Drug: Remifentanil+clonidine

4

Experimental group

Description:

Remifentanil+clonidine

Treatment:

Drug: Remifentanil+clonidine

3

Placebo Comparator group

Description:

Placebo

Treatment:

Drug: Remifentanil+clonidine