Clopidogrel in High-risk Patients With Acute Non-disabling Cerebrovascular Events (CHANCE)

Capital Medical University

Status and phase

Completed

Phase 3

Conditions

Stroke

Transient Ischemic Attack

Treatments

Drug: Placebo of clopidogrel and Asprin

Drug: Clopidogrel

Study type

Interventional

Funder types

Other

Identifiers

NCT00979589

2008ZX09312-008

Details and patient eligibility

About

The purpose of this study is to assess the effects of a 3-month regimen of clopidogrel initiated with a loading dose (LD) of 300 mg followed by 75 mg/day during the first 21days versus a 3-month regimen of ASA 75 mg/day alone on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in high-risk patients with TIA or minor stroke.

Full description

Inclusion criteria:

Adult subjects (male or female ≥ 40 years)
Acute non-disabling ischemic stroke (NIHSS≤3 at the time of randomization) that can be treated with study drug within 24 hours of symptoms onset. Symptom onset is defined by the "last see normal" principle.
TIA (Neurological deficit attributed to focal brain ischemia, with resolution of the deficit within 24 hours of symptom onset), that can be treated with study drug within 24 hours of symptoms onset and with moderate-to-high risk of stroke recurrence (ABCD2 score ≥ 4 at the time of randomization). Symptom onset is defined by the "last see normal" principle.
Informed consent signed

Primary Efficacy Endpoint:

Percentage of patients with the 3-month new vascular events, defined as any event of the following:Any stroke (ischemic or hemorrhage).

Enrollment

5,100 patients

Sex

All

Ages

40 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult subjects (male or female≥40 years)
Acute non-disabling ischemic stroke (NIHSS≤3 at the time of randomization) that can be treated with study drug within 24 hours of symptoms onset. Symptom onset is defined by the "last see normal" principle
TIA (Neurological deficit attributed to focal brain ischemia, with resolution of the deficit within 24 hours of symptom onset), that can be treated with study drug within 24 hours of symptoms onset and with moderate-to-high risk of stroke recurrence (ABCD2 score≥4 at the time of randomization).Symptom onset is defined by the "last see normal" principle
Informed consent signed

Exclusion criteria

Diagnosis of hemorrhage or other pathology, such as vascular malformation, tumor, abscess or other major non-ischemic brain disease (e.g., multiple sclerosis) on baseline head CT or MRI
Isolated or pure sensory symptoms (e.g., numbness), isolated visual changes, or isolated dizziness/vertigo without evidence of acute infarction on baseline head CT or MRI
Modified Rankin Scale Score>2 at randomization (pre-morbid historical assessment)
NIH Stroke Score≥4 at randomization
Clear indication for anticoagulation(presumed cardiac source of embolus, e.g., atrial fibrillation, prosthetic cardiac valves known or suspected endocarditis)
Contraindication to clopidogrel or ASA
Known allergy
Severe renal or hepatic insufficiency
Severe cardiac failure, asthma
Hemostatic disorder or systemic bleeding
History of hemostatic disorder or systemic bleeding
History of thrombocytopenia or neutropenia
History of drug-induced hematologic or hepatic abnormalities
Low white blood cell (<2 x109/l) or platelet count (<100 x109/l)
Use of thrombolysis within 24 hours prior to randomization
History of intracranial hemorrhage
Anticipated requirement for long-term non-study antiplatelet drugs, or NSAIDs affecting platelet function
Current treatment (last dose given within 10 days before randomization) with heparin therapy or oral anti coagulation
Gastrointestinal bleed or major surgery within 3 months
Planned or likely revascularization (any angioplasty or vascular surgery) within the next 3 months (if clinically indicated, vascular imaging should be performed prior to randomization whenever possible)
Scheduled for surgery or interventional treatment requiring study drug cessation
Qualifying TIA or minor stroke induced by angiography or surgery
Severe non-cardiovascular comorbidity with life expectancy < 3 months
Women of childbearing age not practicing reliable contraception who do not have a documented negative pregnancy test
Currently receiving an investigational drug or device