Closed-loop Anaesthesia for Liver Transplantation: a Pilot Study (THConcentr)

Hopital Foch

Status: Completed

Conditions: Liver Transplant; Anesthesia

Treatments: Device: Automated titration of propofol and remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT03357900

2009-A00363-54 (Other Identifier)

2009/09

Details and patient eligibility

About

Automated titration of propofol and remifentanil guided by the bispectral index (BIS) has been used for numerous surgical procedures. Orthotopic liver transplantation (OLT) uniquely combines major volaemic changes, an anhepatic phase, and ischaemia-reperfusion syndrome. We assessed the behaviour of this automated controller during OLT

Enrollment: 12 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients scheduled for OLT

Exclusion criteria

age younger than 18 years, pregnancy, allergy or hypersensitivity to propofol or remifentanil, a medical history of psychiatric illness, and supraspinal neurological disorders

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

Orthotopic liver transplantation

Experimental group

Treatment:

Device: Automated titration of propofol and remifentanil