Cloxacillin as Prevention of Double Lumen Infection in Hemodialysis Patients

Shiraz University of Medical Sciences

Status: Completed

Conditions: Hemodialysis; Double Lumen Infection

Treatments: Drug: heparin; Drug: cloxacillin

Study type: Interventional

Funder types: Other

Identifiers

NCT00885300

3705

Details and patient eligibility

About

The purpose of this study is to investigate whether cloxacillin lock is effective in prevention of double lumen infection.

Full description

Double lumen infection is one of the causes of morbidity and mortality in hemodialysis patients. Many strategies used to prevent it and one of them is antibiotic lock. Thus we select chronic hemodialysis patients and divided them into 2 groups. One group received cloxacillin and heparin as catheter lock and the second group received only heparin lock.

Enrollment: 100 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• hemodialysis for 3 months
• at least 2 time dialysis/week

Exclusion criteria

• active infection
• acute renal failure

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

1

Experimental group

Description:

cloxacillin 100 mg/ml + heparin 1000iu/ml as catheter lock at the end of hemodialysis

Treatment:

Drug: heparin

Drug: cloxacillin

2

Active Comparator group

Description:

heparin 1000iu/ml as catheter lock at the end of hemodialysis

Treatment:

Drug: heparin