Cluster Headache and SPINK-1 Gene

Public Assistance-Hospitals of Marseille (AP-HM)

Status: Completed

Conditions: Episodic or Chronic Cluster Headache

Treatments: Genetic: blood sample

Study type: Interventional

Funder types: Other

Identifiers

NCT02585739

2011-19

RC12_3011 (Other Identifier)

Details and patient eligibility

About

Cluster headache (CH) is a rare, excruciating primary headache disorder. A genetic basis has been suggested by family and twin studies, but the mode of transmission seems to vary and the amount of heritability is unclear.

The number of genetic association studies investigating variants implicated in the pathophysiology of CH is limited. The HCRTR2 1246G > A and the ADH4 925A > G polymorphisms have been associated with CH. The former has been confirmed and may affect the hypothalamic hypocretin system. The aim of the present study was to investigate the possible link between SPINK 1 gene and cluster headache.

Enrollment: 42 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• People aged 18 or over
• Patient consulting in Marseille's or Nice's Pain departments
• Patient agreeing to participate to the research study
• Patient with health insurance

Exclusion criteria

• People aged under 18
• Patient refusing to participate to the research study
• Patient with deprivation of liberty

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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42 participants in 2 patient groups

patient

Experimental group

Description:

patient with Cluster headache

Treatment:

Genetic: blood sample

healthy subject

Other group

Description:

patient without Cluster headache

Treatment:

Genetic: blood sample