CMR Exercise Stress Testing in HFpEF (HFpEF-Stress)

University of Göttingen

Status: Completed

Conditions: Diastolic Heart Failure

Treatments: Diagnostic Test: stress CMR

Study type: Interventional

Funder types: Other

Identifiers

NCT03260621

35/8/15

Details and patient eligibility

About

Patients of the University Hospital Göttingen with echocardiographic signs for diastolic heart failure and indication for right heart catheterisation will undergo additional diagnostic testing with CMR including exercise stress for detailed evaluation of diastolic dysfunction and tissue characterisation correlating the results with well-established clinical standards.

Enrollment: 75 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients with dyspnoea under stress, echocardiographic criteria for diastolic dysfunction (E/E'>8) and clinical indication for right heart catheterisation

Exclusion criteria

• arrhythmia (brady- or tachycardic)
• bronchial asthma (allergic)
• incompliant patient
• pacemaker, ICD, non MRI-capable devices
• inability to use the ergometer in the MRI
• haemodynamic relevant valvular heart disease
• pulmonary disease (vital capacity or forced expiratory flow <80% of healthy control)
• angina pectoris
• post cardiac infarction
• anaemia (Hb <12 g/dl)
• uncontrollable hypertension (>150 mmHg systolic or >100 mmHg diastolic)
• age <18 years
• pregnancy
• claustrophobia
• renal insufficiency
• allergic to gadolinium based contrast agents

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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75 participants in 2 patient groups

echocardiographic increase in left atrial pressure

Other group

Treatment:

Diagnostic Test: stress CMR

echocardiographic no increase in left atrial pressure

Other group

Treatment:

Diagnostic Test: stress CMR