CMR in T2DM: The NSR Cohort

Slagelse Hospital

Status: Invitation-only

Conditions: Myocardium; Fibrosis; Cardiovascular Magnetic Resonance Imaging; Coronary Microvascular Dysfunction; Diabetic Cardiomyopathies; Diabetes Mellitus, Type 2

Treatments: Diagnostic Test: All subjects will undergo cardiac magnetic resonance imaging with gadolinium contrast and with adenosine myocardial perfusion

Study type: Observational

Funder types: Other

Identifiers

NCT05915260

SJ-992

Details and patient eligibility

About

This study aims to investigate the myocardial phenotype of patients with type 2 diabetes. From 2016-2019 the investigators recruited a cohort of 296 subjects with type 2 diabetes. All subjects underwent clinical examinations including a gadolinium contrast cardiac MRI.

The current study is a clinical follow-up study of the subjects, thus, the investigators will invite all participants to a reevaluation with cardiac MRI.

Additionally, the investigators will aim at recruiting additionally 400 patients with type 2 diabetes.

The aim it to characterize the phenotype of diabetic cardiomyopathy. Uniquely using cardiac MRI we can measure myocardial microvascular function, myocardial localised and diffuse fibrosis in addition to the quantification of myocardial structure and systolic and diastolic function.

Enrollment: 700 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Few and simple, allowing for a broad cohort.

• Male or female fully capable of providing informed consent
• Informed consent
• Age 18-80 (both included)
• T2DM diagnosed at least 3 months prior to inclusion in the study

Exclusion Criteria:

Trial design

700 participants in 2 patient groups

Patients with type 2 diabetes

Description:

This group will be split up into different groups. DM2 with vs. without complications to diabetes DM2 with vs. without albuminuria/nephropathy or autonomic neuropathy or retinopathy or peripheral neuropathy or macrovascular angiopathy

Treatment:

Diagnostic Test: All subjects will undergo cardiac magnetic resonance imaging with gadolinium contrast and with adenosine myocardial perfusion

sex and age matched control subjects

Treatment:

Diagnostic Test: All subjects will undergo cardiac magnetic resonance imaging with gadolinium contrast and with adenosine myocardial perfusion