Co-induction Technique Compared to Standard Inhalational and Intravenous Induction Techniques

University of Jordan

Status: Completed

Conditions: Anesthesia; Adverse Effect; Anesthesia

Treatments: Drug: Induction using propofol and sevoflurane; Drug: Induction using sevoflurane; Drug: Induction using propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT04284644

10/2016/4597

Details and patient eligibility

About

Co-induction technique refers to the use of a combination of medications to reach the desired therapeutic target. In the present study, the investigators examined the safety of a novel co-induction approach that relied on a simple timing and dosing alterations to the classical approaches of inhalational sevoflurane and propofol induction. The significance of this study is to find a reliable safe alternative method of induction that can provide optimal parameters,when compared to the classical methods of induction.

Full description

Co-induction technique refers to the use of a combination of medications to reach the desired therapeutic target. This technique is considered an approach that can be of a great benefit to patients with chronic medical illnesses and those who have moderate to high risk for general anaesthesia.

In the present study, the investigators examined the safety of a novel co-induction approach that relied on a simple timing and dosing alterations to the classical approaches of inhalational sevoflurane and propofol induction. The significance of this study is to find a reliable safe alternative method of induction that can provide optimal parameters,when compared to the classical methods of induction. The investigators evaluated the time needed for laryngeal mask airway (LMA) insertion, number of LMA insertion trials, succession of LMA insertion, adverse events related to the airway, respiratory and cardiovascular systems, haemodynamic stability and satisfaction scores of enrolled patients.

Enrollment: 105 patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with Age ≥ 65 years.
• American Society of Anaesthesiologists' (ASA) score II or III.
• minimally invasive endoscopic urological procedures.

Exclusion criteria

• patient refusal.
• Age < 65 years.
• family history of malignant hyperthermia.
• prolonged surgery that needed intubation.
• body mass index (BMI) > 35 kg/m2.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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105 participants in 3 patient groups

Group P

Experimental group

Description:

Patient received a dose of 1.5 mg/kg of Propofol slowly over 2 minutes for induction.

Treatment:

Drug: Induction using propofol

Group S

Experimental group

Description:

Patient received 8% sevoflurane through sealed plastic facemask at 8 L/min flow of oxygen.

Treatment:

Drug: Induction using sevoflurane

Group C

Experimental group

Description:

Patient received 4% sevoflurane through sealed plastic facemask at 8 L/min flow of oxygen for 2 minutes, followed by a dose of 0.75 mg/kg of propofol given slowly.

Treatment:

Drug: Induction using propofol and sevoflurane